Pilot Vacuum Freeze Dryer
Pilot Vacuum Freeze Dryer
Pilot vacuum freeze dryers engineered for laboratory-scale process optimization, formulation research, and small-batch trial production. These systems feature precise shelf temperature control, independent refrigeration circuits, and 316L stainless steel sanitary chambers to establish exact freezing and drying curves before scaling to industrial lines.
Key Specifications & Quick Decision Guide
Model Range
Available in FD-05P (benchtop, 0.12 - 0.25 m² shelf area), FD-10P (floor-standing, 0.50 - 1.00 m²), and FD-30P (production pilot, 1.50 - 3.00 m²) series.
01
Temperature & Condenser
Condenser temperatures reach <= -55°C or -75°C to -85°C with ice condenser capacities ranging from 5 to 40 kg/24h.
02
Chamber Build
Ra <= 0.6 μm electro-polished 316L stainless steel interior paired with a 304 stainless steel exterior frame.
03
Control & Data
Siemens PLC with an industrial touch-panel HMI supporting FDA 21 CFR Part 11 compliant real-time data logging and remote diagnostic integration.
04
Vacuum Performance
Two-stage rotary vane pump paired with a Roots blower delivering ultimate vacuum pressure < 5 Pa in a dry and clean chamber.
05
Product Range & Technical Comparison Table
|
Model Series |
Shelf Area (m²) |
Condenser Temperature (°C) |
Condenser Capacity (kg/24h) |
Main Applications |
|
FD-05P (Benchtop) |
0.12 - 0.25 |
<= -55 or -80 |
5 - 8 |
Lab formulation, small peptides |
|
FD-10P (Floor-standing) |
0.50 - 1.00 |
<= -75 or -85 |
10 - 15 |
Pilot plant scale, clinical trial batching |
|
FD-30P (Production Pilot) |
1.50 - 3.00 |
<= -75 or -85 |
30 - 40 |
Small-batch biological manufacturing |
Technical Specifications & Architecture
Shelf Configuration
Radiant heating shelves filled with medical-grade silicone oil heat transfer fluid, maintaining a temperature uniformity of <= ± 1°C. Standard maximum shelf temperature reaches +60°C (optional high-temperature configuration up to +80°C).
Refrigeration System
Independent refrigeration using dual-stage hermetic compressors (Bitzer/Danfoss) with R404A/R507 refrigerants.
Utility Requirements
Operates on 380V/50Hz/3Ph or 208-230V/60Hz/3Ph power supplies, with a chilled water supply requirement of 15°C to 20°C for condenser cooling, compressed air (>= 0.6 MPa), and a dedicated room ventilation system.
Applications
Pharmaceuticals
Suitable for freeze-drying heat-sensitive injectables, vaccines, antibiotics, enzymes, and diagnostic reagents.
Biotechnology
Applied in preserving live attenuated bacteria, blood plasma derivatives, and nanoparticle delivery systems.
Food Science & Material Science
Used for high-value nutrient retention research, probiotics, porous ceramic matrices, aerogels, and nano-powders requiring strict particle structure retention.
Selection & Operational Constraints
Batch Mass Sizing: Total water content per batch must be calculated (e.g., an 8 kg ice vapor load from a 10 kg batch with 80% moisture) to ensure condenser capacity exceeds the volume with a 20% safety margin.
Loading Method: Vial processing requires built-in hydraulic or pneumatic stoppering mechanisms, whereas bulk tray drying utilizes open-face shelving with high thermal transfer rates.
Solvent Compatibility: Standard units handle aqueous solutions; organic solvent applications (such as tert-butanol or ethanol) require explosion-proof electrical ratings (ATEX-rated motors, solvent traps), inert gas purging, and chemical-resistant diaphragm vacuum pumps.
Customization & Quality Control
Optional Enhancements
Includes pneumatic top-down stoppering mechanisms for serum vials, automated Clean-in-Place (CIP) and Sterilize-in-Place (SIP) systems with pure steam sterilization ports, eutectic point test probes, and direct flange mounting for isolation gloveboxes.
Compliance & Testing
Pressure vessels are manufactured strictly according to ASME Section VIII / PED 2014/68/EU standards and tested at 1.5x operating pressure. Every unit undergoes helium mass spectrometer leak testing (leak rate < 1 x 10^-7 Pa·m³/s) and a 72-hour Factory Acceptance Testing (FAT) dry-run, vacuum hold test, and thermal mapping report prior to shipment. Standard catalog configurations ship within 8 to 10 weeks, while custom units with CIP/SIP or specialized stoppering require 14 to 18 weeks.
Frequently Asked Questions
We're known as one of the most reliable pilot vacuum freeze dryer manufacturers and suppliers in China. Please rest assured to buy high-grade pilot vacuum freeze dryer for sale here from our factory. All customized machines are with high quality and competitive price.
freeze vacuum dryer, fruit freeze dryer machine, industrial freeze dryer machine