Laboratory vacuum freeze-drying equipment executes sublimation under controlled vacuum and low-temperature conditions. This process removes solvents or water from heat-sensitive biological, pharmaceutical, and chemical samples while preserving molecular structure and biological activity.
Standard configurations integrate a hermetic refrigeration circuit, a 316L stainless steel drying chamber, a precision vacuum module, and a PLC automation terminal. Operational parameters-including shelf thermal gradients, condenser cooling curves, and chamber vacuum thresholds-are programmable to match specific eutectic point requirements. Manufactured systems comply with ISO 9001 quality standards and hold CE safety certification.
Product Range
|
Model Series |
Configuration Type |
Condenser Temperature |
Condenser Capacity |
Shelf Area |
Primary Application |
|
FD-10B |
Benchtop (Top Press) |
-50 deg C |
3 kg / 24h |
0.12 m2 |
Routine biological sample prep, peptides |
|
FD-50T |
Floor Standing (Manifold/Stoppering) |
-80 deg C |
5 kg / 24h |
0.20 m2 |
Pharmaceutical R&D, heat-sensitive enzymes |
|
FD-100P |
Pilot Scale (External Condenser) |
-80 deg C |
10 kg / 24h |
0.50 m2 |
Clinical trial batch production, scale-up |
Technical Specifications
|
Specification |
Details |
|
Condenser Lowest Temperature |
-50 deg C, -80 deg C (Cascade system; R404A/R23 CFC-free refrigerants). |
|
Ultimate Vacuum Pressure |
Less than 5 Pa (Unloaded, Pirani gauge; holding leak rate less than 10 Pa*L/s). |
|
Shelf Temperature Range |
-55 deg C to +70 deg C (Control precision: +/- 1 deg C; thermal uniformity less than or equal to +/- 1.5 deg C). |
|
Defrost Mechanism |
Integrated electric heating coil for rapid defrosting. |
|
Chamber Material |
316L pharmaceutical-grade stainless steel (Mirror finish: Ra less than or equal to 0.4 um). |
|
Control Architecture |
Siemens S7-1200 PLC with 7-inch industrial touch panel; supports 36 programs (40 thermal segments per program). |
|
Data Compliance |
USB/Ethernet data export conforming to 21 CFR Part 11 audit trail requirements. |
|
Power Configuration |
220V/50Hz or 110V/60Hz options available. |
Applications
Pharmaceutical Formulation: Lyophilization of vaccines, antibiotics, monoclonal antibodies, and diagnostic reagents.
Biological Sample Processing: Preservation of live bacteria, viruses, blood plasma, and tissue samples.
Material Science: Preparation of aerogels, nanoparticles, and porous ceramic precursors.
Botanical Research: Stabilization of temperature-sensitive antioxidants and plant extracts.
Selection Guide
★Calculate Moisture Load: Determine maximum liquid volume per batch (kg). Condenser capacity must exceed water load by greater than or equal to 30% to prevent endpoint overloading.
★Determine Condenser Temperature:
50 deg C: Aqueous solutions with eutectic points above -40 deg C.
80 deg C: Formulations containing low-boiling organic solvents, carbohydrates, or low glass transition temperatures (Tg').
★Select Stoppering Mechanism:
Manifold Type: Bulk flasks, ampoules, and serum bottles without in-vial sealing.
Stoppering Type: Pneumatic hydraulic sealing of rubber stoppers inside the chamber under vacuum.
Customization Options
Vacuum Pump Integration: Edwards/Leybold oil-sealed rotary vane pumps or oil-free scroll dry vacuum pumps.
Eutectic Point Sensor: Built-in resistance probe for real-time monitoring of freezing and collapse points.
Cleanroom Integration: Through-wall configuration with front-loading chambers and sterile barrier flanges.
Electrical Standards: Panels built for regional electrical compliance (UL/CSA certification options).
Quality Control & Validation
Leak Detection: Chamber assemblies tested via helium mass spectrometry down to 1 x 10^-9 Pa*m3/s.
Thermal Mapping: 9-point shelf temperature validation using calibrated thermocouple arrays. Individual test reports ship with units.
Electrical Safety: Insulation resistance (greater than or equal to 20Mohm) and dielectric withstand voltage testing executed per IEC 61010-1.
Material Traceability: 3.1 mill test certificates for 316L stainless components archived for 10 years.
Packaging & International Shipping
Crate Structure: Fumigation-free plywood crate lined with moisture-barrier vacuum foil and high-density EPE foam.
Accessory Kit: Vacuum oil, silicone gaskets, calibration certificates, and matching connection flanges included.
Logistics Compliance: Optimized for standard air freight pallets and 20-foot containers. Hazardous material declarations handled for refrigeration compressors.
Technical Support & After-Sales Service
Documentation Package: Delivered with English user manuals, electrical schematics, PLC program logic lists, and IQ/OQ protocols.
Installation: Remote video engineering support; on-site commissioning available upon contract agreement.
Warranty: 12-month standard warranty on mechanical/electrical parts; 3-year factory warranty on compressor units.
Spare Parts: Critical components (solenoid valves, vacuum gauges, door seals) stocked locally for 48-hour dispatch.
Frequently Asked Questions
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