Laboratory Trial Freeze Dryers bridge benchtop formulation testing and pilot-scale production. Designed for research institutes, pharmaceutical laboratories, and contract manufacturing organizations (CMOs), these systems determine critical process parameters (CPPs) including collapse temperature, primary drying rates, and desorption endpoints.
Granular control over shelf thermal profiles and chamber pressure ensures seamless scale-up to production units without reformulation failure. Built within our ISO-certified facility, each system undergoes rigorous component matching and factory floor assembly.
Product Range
|
Model Series |
Ice Condenser Capacity |
Shelf Area |
Min. Condenser Temp. |
Primary Application |
|
LTF-10 |
10 kg / 24h |
0.12 m2 |
<= -55°C / -80°C |
Early-stage formulation & peptide R&D |
|
LTF-30 |
30 kg / 24h |
0.35 m2 |
<= -80°C |
Vaccine stabilization & clinical batch prep |
|
LTF-50 |
50 kg / 24h |
0.70 m2 |
<= -80°C |
Pilot-scale scale-up & small-batch production |
Technical Specifications
|
Parameter Category |
Technical Specification |
Engineering Details & Standards |
|
Refrigeration & Condenser |
Condenser Temperature |
<= -80°C (Dual-stage hermetic refrigeration, CFC-free refrigerants R404A/R508B) |
|
Ice Condenser Capacity |
10 kg to 50 kg / 24h (Configurable by model series) |
|
|
Defrost System |
Automated hot-gas rapid defrost cycle |
|
|
Shelf & Chamber |
Shelf Temperature Range |
-55°C to +70°C (Control accuracy: +/- 1°C) |
|
Shelf Configuration |
3 to 5 modular shelves (316L stainless steel, surface roughness Ra <= 0.5 um) |
|
|
Ultimate Vacuum Pressure |
< 5 Pa (Clean, dry chamber) |
|
|
Control & Automation |
Control Architecture |
Siemens PLC coupled with a 10-inch color HMI |
|
Software Capabilities |
Automated profile execution, manual override, and real-time SCADA data logging |
|
|
Data Integrity |
21 CFR Part 11 compliant audit trails and electronic signatures (Optional) |
|
|
Utilities & Compliance |
Power Supply |
220V / 380V, 50/60Hz, 3-phase |
|
Electrical Standards |
CE and UL-compliant control panel construction, IEC 61010-1 safety tested |
|
|
Vacuum Sealing Options |
Pneumatic bottom-up/top-down stoppering mechanism |
Applications
Pharmaceutical Formulations: Lyophilization of monoclonal antibodies, vaccines, enzymes, and antibiotics.
Biological Samples: Preservation of blood plasma, bacterial strains, viral vectors, and diagnostic reagents.
Material Science: Drying of metal oxide nanoparticles, polymers, and porous catalysts.
Food & Botanical R&D: Bioactive compound stabilization and reference sample preparation.
Customization Options
Stoppering Mechanisms: Pneumatic bottom-up/top-down vial sealing under vacuum or inert gas.
Vacuum Modulation: Proportional control valves for precise chamber pressure adjustment via sterile nitrogen injection.
Instrumentation: Pirani and capacitance manometers (Baratron) for dual-range vacuum sensing; dedicated product thermocouples.
Inert Purging: Mass flow controller (MFC) integrated ports for nitrogen/argon backfilling.
Quality Control
Material Verification: Positive Material Identification (PMI) on all 316L product-contact surfaces, backed by EN 10204 3.1 certificates.
Pressure Testing: Hydrostatic testing of condenser coils and shelf circuits at 1.5x maximum allowable working pressure.
Leak Detection: Helium mass spectrometer testing on chambers and welds (leak rate < 1 x 10^-9 Pa*m3/s).
Electrical Safety: Dielectric strength and insulation resistance testing per IEC 61010-1.
Packaging & International Shipping
Crates: ISPM 15 heat-treated wooden crates with internal elastomer shock absorbers.
Moisture Barriers: Vacuum-sealed barrier foil wrapping containing indicating silica gel desiccant.
Documentation: FAT protocols, material certificates, sensor calibration logs, and electrical/piping schematics included.
Technical Support & After-Sales Service
Warranty & SL12-month standard international warranty with a guaranteed 24-hour remote technical response SLA.
Commissioning: Digital installation guides, remote video support, and optional on-site IQ/OQ validation services.
Spare Parts: Regional stocking of critical replacement items (vacuum pump rebuild kits, solenoid valves, heating elements).
Remote Diagnostics: Ethernet-enabled HMI access for secure fault diagnosis and PID tuning.
Frequently Asked Questions
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